Medicine

Difference Between Zyrtec and Claritin

Main difference

The main difference between Zyrtec and Claritin is that Zyrtec is the brand name for Cetirizine Hydrochloride and Claritin is the brand name for Loratadine Hydrochloride.

Zyrtec vs. Claritin

Zyrtec contains cetirizine hydrochloride while Claritin contains loratadine hydrochloride. Zyrtec starts to show its therapeutic action after 59-126 minutes of dosing, while it starts to show its therapeutic action after 102 minutes of dosing. Claritin Zyrtec has a duration of action of 12-24 hours, while Claritin has a duration of action of 24 hours. . Zyrtec is available in 5-10mg doses, while Claritin is available in 10mg doses. Zyrtec is not metabolized by the cytochrome P450 enzyme system while Claritin is metabolized by the cytochrome P450 enzyme system. Zyrtec is a piperazine antihistamine, while Claritin is a piperidine antihistamine. Zyrtec does not interact with cytochrome P450 enzyme inducers or inhibitors, while Claritin interacts with inducers or inhibitors of the cytochrome P450 enzyme. Zyrtec has no active metabolite,

Comparison chart

Zyrtech Claritin
Zyrtec is an antihistamine containing cetirizine hydrochloride as the active therapeutic agent. Claritin is loratadine hydrochloride containing antihistamines as the active therapeutic agent.
drug category
antihistamines antihistamines
Receptors on which the drug acts
H1 receptors H1 receptors
Action mode
Block H1 receptors Block H1 receptors
duration of action
12-24 hours 24 hours
Preparations
Tablets, Syrups Tablets, suspensions, syrups
therapeutic uses
sneezing
runny nose
Urticaria
Itchy eyes or nose
Allergic rhinitis
Urticaria
Hay fever
Urticaria
Adverse effects
Headache
Fatigue
Dry mouth
Drowsiness
antimuscarinic effects
minute sedation
psychomotor retardation minute

What is Zyrtec?

Zyrtec is the antihistamine and is the brand name for cetirizine hydrochloride. Zyrtec belongs to the second generation of antihistamines. Zyrtec is used to treat allergy symptoms including sneezing, itchy eyes or nose, runny nose, and hives. Zyrtec blocks the pharmacological actions of histamine, which is a natural substance and is released in response to exposure to any other type of allergen. Zyrtec does not prevent or treat a serious allergic reaction such as anaphylaxis. The cetirizine in Zyrtec is a selective H1 receptor blocker. Cetirizine has 600 times more selectivity for H1 receptors than any other type of receptor. Only a small amount of cetirizine crosses the blood-brain barrier, so it causes less sedation. Cetirizine 10 mg occupies approximately 12% of H1 receptors, cetirizine 20 mg occupies approximately 25% of H1 receptors, and cetirizine 30 mg occupies approximately 67% of H1 receptors in the brain. Cetirizine also inhibits eosinophil chemotaxis. The cetirizine in Zyrtec is rapidly absorbed after oral administration with an oral bioavailability of 70%. Zyrtec begins to show its pharmacological actions after 20 minutes of dosing. Cetirizine is not extensively metabolized and is not even metabolized by the cytochrome P450 enzyme system, therefore it does not show any drug-drug interaction with drugs that are inducers or inhibitors of the cytochrome P450 enzyme. Cetirizine in Zyrtec is metabolized by oxidation and conjugation. Cetirizine in Zyrtec is excreted 70-85% in the urine and 10-13% in the feces. Zyrtec is an over-the-counter medication. The dose of Zyrtec depends on the patient’s age, medical condition, and response to treatment. If allergy symptoms or hives persist after three days of treatment with Zyrtec, see a doctor. Side effects of Zyrtec are dry mouth, dizziness and tiredness. Zyrtec overdose can cause shortness of breath. Zyrtec is not prescribed for patients allergic to hydroxyzine. Side effects of Zyrtec are dry mouth, dizziness and tiredness. Zyrtec overdose can cause shortness of breath. Zyrtec is not prescribed for patients allergic to hydroxyzine. Side effects of Zyrtec are dry mouth, dizziness and tiredness. Zyrtec overdose can cause shortness of breath. Zyrtec is not prescribed for patients allergic to hydroxyzine.

What is Claritin?

Claritin is the antihistamine and is the brand name for loratadine hydrochloride. Claritin belongs to the 2ndgeneration of antihistamines. Claritin is used to treat hives and allergic rhinitis. Claritin is similar in structure to TCA and the antipsychotic quetiapine. Claritin is taken orally. The loratidine in Claritin is a tricyclic antihistamine and acts as an inverse agonist at peripheral H1 receptors. Claritin is rapidly absorbed from the GIT when taken orally and rapidly undergoes first-pass hepatic metabolism. Claritin is metabolized by the cytochrome P450 enzyme system. 90-97% of loratadine in Claritin is bound to plasma proteins. Claritin when metabolized, its metabolite desloratadine 73-76% binds to plasma proteins, and desloratadine is also responsible for the antihistamine effects of Claritin. The maximum plasma concentration of Claritin is reached in 1-2 hours and the half-life of Claritin is approximately 8 hours. and together with the half-life of desloratadine is 27 hours. Claritin is excreted in the urine and a small amount in the feces. Unmetabolized claritin is also excreted in the urine. Claritin does not prevent or treat hives or allergic reactions. Claritin tablets or capsules should not be used in children under 6 years of age. Claritin chewable tablets or liquids should not be used without a prescription in children younger than 2 years of age. Claritin is an over-the-counter drug. Claritin can be taken with or without food; if Claritin is taken in liquid form, your dose should be measured with a measuring spoon. Claritin dosage can be adjusted based on age and severity of allergy; The dose can also be adjusted based on response to treatment. Claritin should not be used if the patient is allergic to the active drug loratadine or the active metabolite desloratadine. Claritin in recommended doses does not cause drowsiness, but it is recommended not to operate machinery after taking it.

Key differences

  1. Zyrtec has cetirizine hydrochloride as the active therapeutic agent, while Claritin has loratadine hydrochloride as the active therapeutic agent.
  2. Zyrtec produces therapeutic effects for 12-24 hours, while Claritin produces therapeutic effects for 24 hours.
  3. Zyrtec has an onset of action of 59 minutes to 126 minutes, while Claritin has an onset of action of 102 minutes.
  4. Zyrtec is not metabolized by the cytochrome P450 enzyme system, while Claritin is metabolized by the cytochrome P450 enzyme system.
  5. Zyrtec is chemically piperazine while Claritin is chemically piperidine.
  6. Zyrtec does not have an active metabolite while Claritin has an active metabolite.
  7. Zyrtec is available as a tablet and syrup, while Claritin is available as a tablet, syrup, and suspension.
  8. The available concentration of Zyrtec is 5-10mg, while the available concentration of Claritin is 10mg.
Final Thoughts

The main takeaway from the above discussion is that both Zyrtec and Claritin are used for the treatment of allergies.

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