Difference Between Zyrtec and Benadryl

Main difference

The main difference between Zofran and Phenergan is that Zofran has Ondansetron HCL as its active pharmaceutical ingredient while Phenergan has Promethazine as its active pharmaceutical ingredient.

Zyrtec vs. Benadryl

Zyrtec contains cetirizine hydrochloride, on the other hand Benadryl contains diphenhydramine hydrochloride. Zyrtec belongs to second generation antihistamines while Benadryl is first generation antihistamines. Zyrtec causes less sleepiness, on the other hand, Benadryl causes more sleepiness. Zyrtec shows its pharmacological actions for 12-24 hours while Benadryl shows its pharmacological actions for 12 hours. Zyrtec is not prescribed for the treatment of hives, on the other hand, Benadryl is the best option for the treatment of hives. Zyrtec tablet, fast dissolving tablet and liquid are available, on the other hand, Benadryl talent, fast dissolving tablet, liquid and capsules are available. Zyrtec is administered as 5 to 10 mg as a single dose for adults, on the other hand, Benadryl is given at 25 to 50 mg as a single dose for adults. Zyrtec causes less fatigue, on the other hand,

Comparison chart

Zyrtech benadryl
Zyrtec is the brand name for cetirizine hydrochloride and is used to treat allergies. Benadryl is the brand name for diphenhydramine and is used to treat seasonal and other allergies.
drug group
2nd generation antihistamine First generation antihistamine
active therapeutic agent
Cetirizine HCL diphenhydramine hydrochloride
duration of action
12-24 hours 12 hours
Single dose
5-10mg 25-50mg
dosage forms
Tablet, fast dissolving tablet and liquid Tablet, fast dissolving tablet, liquid and capsule.
therapeutic uses
Allergic rhinitis, urticaria, dermatitis Allergies, seasonal allergies including sneezing, itchy throat, and itchy, watery eyes
sleep induction
Under High
What is Zyrtec?

Zyrtec is the trade name for cetirizine hydrochloride which is the 2ndgeneration antihistamine and belongs to the chemical class of piperazine. Zyrtec is used for many immediate hypersensitivity reactions such as allergic rhinitis, hives, and dermatitis. Zyrtec shows its therapeutic actions by blocking HI receptors. Zyrtec begins to show its pharmacological actions within an hour. The effects of Zyrtec’s pharmacological actions last for a day. The therapeutic benefits of Zyrtec are the same as those of diphenhydramine. Zyrtec causes drowsiness as a side effect, but its degree is less than that of first-generation antihistamines. Other side effects of Zyrtec include abdominal pain, headache, and dry mouth. Serious side effects of Zyrtec are angioedema and aggression. Pregnant women can use Zyrtec, but its use in nursing mothers is not recommended. Zyrtec is used in allergies because in allergies, redness is caused by histamine acting on H1 receptors, and because Zyrtec blocks these receptors, it doesn’t allow histamine to cause any further effects. Between all the other 2th generation of antihistamines the Zyrtec is the best option to treat acute or chronic hives. Zyrtec is available in 5, 10, and 20 mg tablets. When Zyrtec is discontinued after prolonged use, patients experience itching. Zyrtec is well absorbed after oral administration in both tablet and syrup form. Zyrtec does not interact with many drugs because it is not metabolized by the cytochrome P450 enzyme system. Zyrtec is metabolized through chemical reactions such as oxidation and conjugation. Zyrtec is eliminated from the body mainly in the urine and, to a lesser extent, in the faeces.

What is Benadryl?

Benadryl is the brand name of diphenhydramine that is classified as an antihistamine. Benadryl salt is diphenhydramine hydrochloride. Benadryl is an over the counter medication. Benadryl is used to treat seasonal allergy symptoms such as sneezing, scratchy throat, and itchy, watery eyes or other allergies; It also relieves the symptoms of old and common itchy skin due to hives or insect bites. Benadryl is considered the treatment of first choice for the treatment of hives. Benadryl is used orally or topically. Benadryl is sold without a prescription. Benadryl causes some drowsiness and is not recommended for children under six years of age. Benadryl gel products contain a high level of the drug and, if ingested by mistake, Benadryl gel products may cause unconsciousness or confusion. Benadryl tablets contain inactive ingredients such as colloidal silicone dioxide, crospovidone, candelilla wax, hypromellose, polyethylene glycol, providone, talc pregelatinized starch, microcrystalline cellulose starch, titanium dioxide, and stearic acid. Benadryl is prescribed in doses of 25 to 50 mg for adults and children 12 years and older. Benadryl is prescribed in doses of 12.5 mg to 25 mg in patients 6 to 12 years of age. Benadryl is prescribed in children under six years of age after consulting a doctor. The 12.5 mg strength is not available in capsule form. Benadryl is light sensitive, so it should be packaged in containers protected from light. Benadryl is stored at a temperature of 59-77 F in a dry place.

Key differences

  1. Zyrtec is a brand name of cetrizine hydrochloride, on the other hand Benadryl is a brand name of diphenhydramine hydrochloride
  2. Zyrtec is a second generation antihistamine, on the other hand, Benadryl is a first generation antihistamine.
  3. Zyrtec has a low tendency to induce sleep, while Benadryl has a high tendency to induce sleep.
  4. Zyrtec is not a better option to treat hives; on the other hand, Benadryl is a better option to treat hives.
  5. Zyrtec has a duration of action of 12 to 24 hours, while Benadryl has a duration of action of 12 hours.
  6. Zyrtec is available as a tablet, fast-dissolving tablet, and liquid, on the other hand, Benadryl is available as a tablet, fast-dissolving tablet, liquid, and capsule.
  7. The single dose of Zyrtec for adults is 5 to 10 mg, while the single dose of Benadryl for adults is 25 to 50 mg.
  8. Zyrtec causes less fatigue compared to Benadryl; on the other hand, Benadryl causes more tiredness compared to Zyrtec.
Final Thoughts

The main takeaway from the above discussion is that both Zyrtec and Benadryl are antihistamines and are used effectively to treat allergies.

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