Medicine

Difference Between Zyban and Wellbutrin

Main difference

The main difference between Zyban and Wellbutrin is that Zyban is used for smoking cessation and Wellbutrin is an antidepressant drug, although both contain the same active therapeutic moiety.

Zyban vs. Wellbutrin

Zyban contains bupropion HCL and is used alone or in combination with other smoking cessation medications. On the other hand, Wellbutrin contains bupropion HCL and is used only for the treatment of depression. Zyban is available as sustained-release tablets, while Wellbutrin is available as film-coated tablets, sustained-release tablets, and extended-release tablets. Zyban is available in 150mg strengths, while Wellbutrin is available in 75, 100, and 150mg strengths.

Comparison chart

zyban wellbutrin
Zyban is a brand that contains bupropion HCL and is used for smoking cessation. Wellbutrin is a brand that contains bupropion HCL and is used as an antidepressant.
Mechanism of action
Zyban inhibits the reuptake of dopamine, norepinephrine, and serotonin in the CNS. Wellbutrin inhibits the reuptake of dopamine, norepinephrine in the CNS.
dosage form
sustained release tablets Film-coated tablets, sustained-release tablets, prolonged-release tablets
Treatment duration
7-12 weeks 7-12 weeks
Goal of therapy
Total abstinence from smoking. Complete treatment of depression.
Drug interactions
Zyban interacts with 811 medications. Wellbutrin interacts with 811 drugs.
signs of overdose
The most prominent sign is seizures, and others are loss of consciousness, tachycardia, hallucinations. · The most prominent sign is seizures, and others are loss of consciousness, tachycardia, hallucinations.
combination therapy
Zyban is also used in combination with the nicotine transdermal system for smoking cessation. Wellbutrin is not given in combination therapy due to its drug interactions with other antidepressant medications.
What is Ziban?

Zyban contains bupropion HCL and is FDA approved for smoking cessation. Bupropion HCL in Zyban belongs to the class of antidepressants. Zyban inhibits the reuptake of dopamine, norepinephrine, and serotonin in the CNS, although the exact mechanism of action for using Zyban for smoking cessation is unknown. Zyban prescription can be refilled. Zyban is taken by mouth. Zyban is taken twice daily and can be taken with or without food, but if using Zyban on an empty stomach causes problems such as an upset stomach, then Zyban should be taken with food in the following doses. Patients should use Zyban for at least one week before quitting smoking. Zyban is sometimes prescribed in combination with nicotine patches for smoking cessation, but this combination causes an increase in blood pressure. When Zyban is used with nicotine patches, then it is strictly recommended that you do not smoke, as too much nicotine in the blood would cause serious side effects. Zyban works best when used regularly. If Zyban doesn’t work after 7 to 12 weeks, tell your doctor. Zyban shows side effects like dry mouth, dizziness, nausea, fatigue, tiredness, excessive sweating and various other side effects but despite various side effects, Zyban is prescribed due to its benefits which are more valuable. Zyban can worsen allergies and even Zyban causes allergies due to its excipients. Zyban should not be used in patients experiencing seizures. Zyban should not be used during pregnancy, although it is used during pregnancy when clearly needed. Zyban can be passed to a nursing child through breast milk. Zyban 150 mg extended-release tablets are prescribed,

What is Wellbutrin?

Wellbutrin is a brand that contains bupropion HCL and unicyclic amino ketones and is used as an antidepressant. Wellbutrin is recommended for the treatment of major depression and seasonal affective disorder. Wellbutrin prescription can be refilled if needed. Bupropion HCL in Wellbutrin is 75 or 100 mg, and in Wellbutrin, SR is 100, 150, and 200 mg. Wellbutrin is initially prescribed as 100 mg orally twice a day or 75 mg 3 times a day, if no response occurs, 100 mg 3 times a day is taken, and the dose may be increased to 150 mg 3 times in case Bupropion HCL in Wellbutrin is metabolized in the liver and its metabolite, hydroxybupropion, is as effective as bupropion itself. Wellbutrin SR is taken twice a day and Wellbutrin XR is taken once a day. Wellbutrin shows drug interactions with drugs whose enzyme inhibitors increase bupropion concentration and decrease hydroxybupropion concentration in blood, and for example, such drugs are orphenadrine, paroxetine, etc. Wellbutrin also shows drug interactions with drugs that induce enzymes in the blood. liver, so they decrease the concentration of bupropion and increase the concentration of hydroxybupripion in the blood, and for example, such drugs are carbamazepine, clotrimazole, etc. Wellbutrin overdose causes abnormal heartbeat, loss of consciousness, hallucinations, some patients die from overdose, and some recover after overdose treatment.

Key differences

  1. Zyban is used for smoking cessation, while Wellbutrin is used for the treatment of depression.
  2. Zyban is available as sustained-release tablets, while Wellbutrin is available as film-coated tablets, sustained-release tablets, and extended-release tablets.
  3. Zyban is available in a single concentration, while Wellbutrin is available in different concentrations.
  4. Zyban can be used in combination therapy while Wellbutrin is not used in combination therapy.
Final Thoughts

The bottom line from the above discussion is that both Zyban and Wellbutrin contain bupropion HCL as the active ingredient, but Zyban is important as it aids smoking cessation and Wellbutrin is important for use as an antidepressant.

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