Medicine

Difference Between Zantac and Omeprazole

Main difference

The main difference between Zantac and Omeprazole is that Zantac is less potent in suppressing gastric acid secretion than Omeprazole.

Zantac versus omeprazole

Zantac is an H-2 receptor blocker; on the other hand, omeprazole is a proton pump inhibitor. Zantac is a brand name, while Omeprazole is a generic term. Zantac contains ranitidine HCl while omeprazole is in its S and R isomer forms. Zantac is suitable for treating nocturnal heartburn while omeprazole suppresses acid secretion within 24 hours equally. Zantac is preferably prescribed for duodenal ulcers; on the other hand, omeprazole is preferably prescribed for gastric ulcers and Zollinger Ellison syndrome. Zantac is not available in powder form while Omeprazole is available in powder form.

Comparison chart

zantac Omeprazole
Zantac is the brand name for ranitidine, an H-2 receptor blocker. Omeprazole is the generic name of one of the proton pump inhibitor drugs.
Receptors on which the drug acts
Zantac acts on H-2 receptors Omeprazole acts on proton pumps
Action mode
Zantac is a mild gastric acid suppressant compared to omeprazole Omeprazole is a potent gastric acid suppressant.
protein binding of the drug
A small percentage of Zantac is protein bound. A large percentage of omeprazole is protein bound.
Available dosage forms
Tablets, Injections Tablets, capsules, powders, parenterals
therapeutic uses
gastric ulcers
Duodenal ulcers
stress ulcers
gastric ulcers
Duodenal ulcers
Zollinger Elison syndrome

what is zantac

Zantac is the brand name for ranitidine, which is an H2 receptor antagonist. Zantac suppresses gastric acid secretions by approximately 70% in 24 hours. Zantac inhibits basal acid secretion, so it is used to suppress nocturnal acid secretion. Zantac is used to treat duodenal ulcers because duodenal ulcers are mainly due to nocturnal heartburn, so it is prescribed at night to treat duodenal ulcers. Zantac increases GI motility, but the therapeutic effect due to this ability is still unknown. Zantac is an over the counter medication. Zantac is rapidly absorbed after oral administration and its maximum serum concentration is reached within 1-3 hours. Zantac is more rapidly absorbed in the presence of food and its absorption is decreased in the presence of antacids. 10%-35% of Zantac is metabolized through the liver. Zantac and its metabolites are excreted via the kidneys, and excretion via the kidneys is important for Zantac dose adjustment in patients who have decreased creatinine clearance. Zantac shows minor side effects like headache, diarrhea, drowsiness, muscle pain. Zantac also affects the central nervous system and confuses slurred speech. Zantac is also reported for blood dyscrasias, including thrombocytopenia. Zantac can cross the placenta and be excreted in breast milk. Zantac, unlike other H2 receptor antagonists, interferes less with hepatic metabolism of other drugs. Zantac not only treats gastric and duodenal ulcers, but also prevents the occurrence of stress ulcers. Zantac shows minor side effects like headache, diarrhea, drowsiness, muscle pain. Zantac also affects the central nervous system and confuses slurred speech. Zantac is also reported for blood dyscrasias, including thrombocytopenia. Zantac can cross the placenta and be excreted in breast milk. Zantac, unlike other H2 receptor antagonists, interferes less with hepatic metabolism of other drugs. Zantac not only treats gastric and duodenal ulcers, but also prevents the occurrence of stress ulcers. Zantac shows minor side effects like headache, diarrhea, drowsiness, muscle pain. Zantac also affects the central nervous system and confuses slurred speech. Zantac is also reported for blood dyscrasias, including thrombocytopenia. Zantac can cross the placenta and be excreted in breast milk. Zantac, unlike other H2 receptor antagonists, interferes less with hepatic metabolism of other drugs. Zantac not only treats gastric and duodenal ulcers, but also prevents the occurrence of stress ulcers.Example

Zantac enteric-coated injectable tablets.

What is omeprazole?

Omeprazole is proton pump inhibitors which are potent suppressors of gastric acid secretions, so omeprazole inhibits proton pumps. Omeprazole inhibits 80% to 90% of basal and stimulated secretion of gastric acid. Omeprazole is also available in its S-isomer form, esomeprazole. Omeprazole is the racemic mixture of its R and S isomers, and the S isomer is eliminated less rapidly than the R isomer. The S isomer of omeprazole has an increased half-life. Omeprazole, like other proton pump inhibitors, is available as a prodrug, which changes to an active form in the presence of an acidic environment. Omeprazole degrades in an acidic environment; To solve this problem, enteric-coated drugs are available in gelatin capsules, enteric-coated tablets and omeprazole powder in combination with sodium carbonate. Omeprazole shows less absorption in the presence of food. Omeprazole when it reaches a small bowl is quickly absorbed. Omeprazole has a high protein-bound concentration. Omeprazole is metabolized by liver enzymes. Omeprazole requires 2 to 5 days of therapy to inhibit 70% of proton pumps. Omeprazole shows adverse effects like headaches, diarrhea, constipation. Omeprazole, when used for long periods of time, decreases the absorption of vitamin B-12. Omeprazole treats gastric and duodenal ulcers, gastroesophageal reflux disease, and Zollinger Ellison syndrome. Omeprazole shows adverse effects like headaches, diarrhea, constipation. Omeprazole, When used for prolonged periods, it decreases the absorption of vitamin B-12. Omeprazole treats gastric and duodenal ulcers, gastroesophageal reflux disease, and Zollinger Ellison syndrome. Omeprazole shows adverse effects like headaches, diarrhea, constipation. Omeprazole, when used for long periods of time, decreases the absorption of vitamin B-12. Omeprazole treats gastric and duodenal ulcers, gastroesophageal reflux disease, and Zollinger Ellison syndrome. When used for prolonged periods, it decreases the absorption of vitamin B-12. Omeprazole treats gastric and duodenal ulcers, gastroesophageal reflux disease, and Zollinger Ellison syndrome. When used for prolonged periods, it decreases the absorption of vitamin B-12. Omeprazole treats gastric and duodenal ulcers, gastroesophageal reflux disease, and Zollinger Ellison syndrome.

Example

Common brands that contain omeprazole are Prilosec, Losec, etc.

Key differences

  1. Zantac is an H-2 receptor antagonist, while omeprazole is a proton pump inhibitor.
  2. Zantac is not extensively protein bound; on the other hand, omeprazole is a drug that is highly protein bound.
  3. Zantac is available in its active form, while omeprazole is available as a prodrug that is activated in an acidic environment.

Final Thought

The conclusion from the above discussion is that Zantac and omeprazole belong to two different drug categories, but both are used to suppress gastric acid secretions.

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