Medicine

Difference Between Zantac and Nexium

Main difference

The main difference between Zantac and Nexium is that Zantac is an H-2 receptor blocker and Nexium is a proton pump inhibitor.

Zantac vs Nexium

Zantac is an H-2 receptor blocker that has a generic drug ranitidine; on the other hand, Nexium is a proton pump inhibitor that has the generic drug esomeprazole. Zantac relieves heartburn and stomach ulcers with side effects, while Nexium relieves heartburn and stomach ulcers with side effects that show long-term. Zantac tablets if difficult to swallow, liquid Zantac preparations are available, while Nexium tablets if difficult to swallow, Nexium packets are available. Zantac is preferably prescribed for duodenal ulcers; on the other hand, Nexium is preferably prescribed for H.Pylori infection. Zantac is a prescription and over-the-counter drug while Nexium is an over-the-counter drug.

Comparison chart

zantac nexium
Zantac is the brand name for ranitidine, an H-2 receptor blocker. Nexium is the generic name for esomeprazole
Receptors on which the drug acts
Zantac acts on H-2 receptors Nexium acts on proton pumps.
Action mode
Zantac is a mild gastric acid suppressant compared to omeprazole. Nexium is a powerful gastric acid suppressant.
protein binding of the drug
A small percentage of Zantac is protein bound. A large percentage of Nexium is protein bound.
Available dosage forms
Pill, Injections, Syrup, Solution pill, injection, pack
therapeutic uses
Acidity
gastric ulcers
Duodenal ulcers
stress ulcers
Acidity
gastric ulcers
H.Pylori infection
NSAID-induced gastric ulcers

what is zantac

Zantac contains ranitidine as an active therapeutic agent. Zantac belongs to H2 receptor antagonist. Zantac can suppress approximately 70% of gastric acid secretions in 24 hours. Zantac can inhibit basal acid secretion. Zantac is also used to suppress nocturnal acid secretion. Zantac has also found use in the treatment of duodenal ulcers as it suppresses nocturnal heartburn, which is why it is prescribed in the evening to treat duodenal ulcers. Zantac has also been found to increase GI motility. Zantac is an over the counter medication. Zantac is rapidly absorbed after oral administration. The maximum serum concentration is reached in 1-3 hours. Zantac is more rapidly absorbed in the presence of food. The absorption of Zantac is decreased if an antacid is taken. Approximately 10%-35% of Zantac is metabolized in the liver. Zantac and its metabolites are excreted via the kidneys. Renal excretion is important for Zantac dose adjustment in renal patients. Zantac shows minor side effects like headache, drowsiness, muscle pain, and diarrhea. Zantac affects the central nervous system and causes difficulty speaking. Zantac is reported for blood dyscrasias. Zantac can cross the placenta and is also excreted in breast milk. Compared to other H2-receptor antagonists, Zantac interferes less with hepatic metabolism of other drugs. Zantac together with the treatment of gastric and duodenal ulcers also prevents the appearance of stress ulcers. Zantac is reported for blood dyscrasias. Zantac can cross the placenta and is also excreted in breast milk. Compared to other H2-receptor antagonists, Zantac interferes less with hepatic metabolism of other drugs. Zantac together with the treatment of gastric and duodenal ulcers also prevents the appearance of stress ulcers. Zantac is reported for blood dyscrasias. Zantac can cross the placenta and is also excreted in breast milk. Compared to other H2-receptor antagonists, Zantac interferes less with hepatic metabolism of other drugs. Zantac together with the treatment of gastric and duodenal ulcers also prevents the appearance of stress ulcers. Zantac interferes less with hepatic metabolism than other drugs. Zantac together with the treatment of gastric and duodenal ulcers also prevents the appearance of stress ulcers. Zantac is reported for blood dyscrasias. Zantac can cross the placenta and is also excreted in breast milk. Compared to other H2-receptor antagonists, Zantac interferes less with hepatic metabolism of other drugs. Zantac together with the treatment of gastric and duodenal ulcers also prevents the appearance of stress ulcers. Zantac interferes less with hepatic metabolism than other drugs. Zantac together with the treatment of gastric and duodenal ulcers also prevents the appearance of stress ulcers. Zantac is reported for blood dyscrasias. Zantac can cross the placenta and is also excreted in breast milk. Compared to other H2-receptor antagonists, Zantac interferes less with hepatic metabolism of other drugs. Zantac together with the treatment of gastric and duodenal ulcers also prevents the appearance of stress ulcers. Compared to other H2-receptor antagonists, Zantac interferes less with hepatic metabolism of other drugs. Zantac together with the treatment of gastric and duodenal ulcers also prevents the appearance of stress ulcers. Compared to other H2-receptor antagonists, Zantac interferes less with hepatic metabolism of other drugs. Zantac together with the treatment of gastric and duodenal ulcers also prevents the appearance of stress ulcers.

Example

Zantac enteric-coated injectable tablets.

What is Nexium?

Nexium is proton pump inhibitors that are potent suppressants of gastric acid secretions. Nexium inhibits basal and stimulated secretion of gastric acid. Nexium is the S isomer of omeprazole. Nexium is eliminated less rapidly than the R isomer of omeprazole. Nexium has an increased half-life. Nexium is available in prodrug form, which changes to an active form in the presence of the acidic environment. Nexium is acid labile, to address this issue it is available as enteric coated medications and in Nexium packets in combination with sodium carbonate. Nexium shows decreased absorption in the presence of food. Nexium has a high protein-bound concentration. Nexium is metabolized by liver enzymes. Nexium reaches maximum plasma concentration in 2-4 hours. Nexium shows side effects like headaches, dark urine, constipation. Nexium treats gastric ulcers, H.

Example

Nexium is available in the form of pills, injections, and packets.

Key differences

  1. Zantac is an H-2 receptor antagonist, while Nexium is a proton pump inhibitor.
  2. Zantac is not extensively protein bound; on the other hand, Nexium is a highly protein-bound drug.
  3. Zantac is available in its active form while Nexium is available as a prodrug that is activated in an acidic environment.
  4. Zantac is not available in package form while Nexium is available in package form.

Final Thought

The conclusion from the above discussion is that Zantac and Nexium belong to two different drug categories, but both are used to suppress gastric acid secretions.

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