Medicine

Difference Between Rizatriptan and Sumatriptan

Main difference

The main difference between Rizatriptan and Sumatriptan is that Rizatriptan has more advantages in the treatment of acute migraine and Sumatriptan has relatively less advantages in the treatment of acute migraine.

Rizatriptan versus sumatriptan

Rizatriptan is the first-line treatment for migraines, while sumatriptan is an excellent option for acute migraines. Rizatriptan is available as rizatriptan benzoate, on the other hand, Sumatriptan Sumatriptan Succinate. Rizatriptan can be recommended for tension-type headaches, on the other hand, sumatriptan is not used for tension-type headaches. hours when the drug is taken orally. Rizatriptan has an oral bioavailability of 45%; on the other hand, sumatriptan has an oral bioavailability of 14% to 17%. Rizatriptan is administered orally, while sumatriptan is administered as oral, nasal, and subcutaneous preparations.

Comparison chart

Rizatriptan Sumatriptan
Rizatriptan is a triptan drug used to treat migraines and is available as rizatriptan benzoate. Sumatriptan is a triptan that treats migraines and is available as sumatriptan succinate.
Mechanism
5HT receptor agonist 5HT receptor agonist
Administration route
Oral Oral, nasal, subcutaneous
rebound headaches
If used in excess it can cause rebound headaches. If used in excess it can cause rebound headaches.
Dose frequency
The second dose can be taken 2 hours after the first dose. The second dose can be taken 1 hour after the first dose.
Adverse effects
Asthenia, fatigue, flushing, pain in the chest, neck and jaw, dizziness Asthenia, bitter taste, fatigue, flushing, pain in the chest, neck and jaw, atrial and ventricular arrhythmias, dizziness

What is Rizatriptan?

Rizatriptan is a triptan drug used to treat migraines. Rizatriptan is taken by mouth. Rizatriptan acts on serotonin receptors and causes vasoconstriction. Rizatriptan inhibits the release of calcitonin gene-related peptide from the trigeminal nerve. The rizatriptan dose should be taken as soon as the headache starts. If rizatriptan is used in excessive doses, it causes medication overuse headaches. Side effects of rizatriptan are dizziness, dry mouth, tingling, and chest pain. Some other side effects are high blood pressure, stroke, heart attack, serotonin syndrome, and anaphylaxis. Rizatriptan is not used during pregnancy and during lactation it is not allowed after 24 hours of taking Rizatriptan. Rizatriptan does not reduce the number of migraine attacks. Rizatriptan is not recommended for headaches, which result from tension. Patients who have a heart problem cannot take rizatriptan. Rizatriptan should not be used before and after 24 hours of migraine. Rizatriptan should not be used within 14 days of MAO inhibitor dosing. Rizatriptan can be taken with or without food, but its absorption is rapid in the fasted state. If symptoms persist after the use of rizatriptan, you should not continue taking the medicine. If the symptoms are partially relieved, the headaches return and, in this case, the next dose is taken 2 hours after the first dose. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Patients who have a heart problem cannot take rizatriptan. Rizatriptan should not be used before and after 24 hours of migraine. Rizatriptan should not be used within 14 days of MAO inhibitor dosing. Rizatriptan can be taken with or without food, but its absorption is rapid in the fasted state. If symptoms persist after the use of rizatriptan, you should not continue taking the medicine. If the symptoms are partially relieved, the headaches return and, in this case, the next dose is taken 2 hours after the first dose. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Patients who have a heart problem cannot take rizatriptan. Rizatriptan should not be used before and after 24 hours of migraine. Rizatriptan should not be used within 14 days of MAO inhibitor dosing. Rizatriptan can be taken with or without food, but its absorption is rapid in the fasted state. If symptoms persist after the use of rizatriptan, you should not continue taking the medicine. If the symptoms are partially relieved, the headaches return and, in this case, the next dose is taken 2 hours after the first dose. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should not be used before and after 24 hours of migraine. Rizatriptan should not be used within 14 days of MAO inhibitor dosing. Rizatriptan can be taken with or without food, but its absorption is rapid in the fasted state. If symptoms persist after the use of rizatriptan, you should not continue taking the medicine. If the symptoms are partially relieved, the headaches return and, in this case, the next dose is taken 2 hours after the first dose. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should not be used before and after 24 hours of migraine. Rizatriptan should not be used within 14 days of MAO inhibitor dosing. Rizatriptan can be taken with or without food, but its absorption is rapid in the fasted state. If symptoms persist after the use of rizatriptan, you should not continue taking the medicine. If the symptoms are partially relieved, the headaches return and, in this case, the next dose is taken 2 hours after the first dose. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. but its absorption is rapid fasting. If symptoms persist after the use of rizatriptan, you should not continue taking the medicine. If symptoms are partially relieved, the headaches return, and in this case the next dose is taken 2 hours after the first dose. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. but its absorption is rapid fasting. If symptoms persist after the use of rizatriptan, you should not continue taking the drug. If symptoms are partially relieved, the headaches return, and in this case the next dose is taken 2 hours after the first dose. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. If symptoms persist after the use of rizatriptan, you should not continue taking the drug. If symptoms are partially relieved, the headaches return, and in this case the next dose is taken 2 hours after the first dose. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. If symptoms persist after the use of rizatriptan, you should not continue taking the drug. If symptoms are partially relieved, the headaches return, and in this case the next dose is taken 2 hours after the first dose. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. you should not continue taking the medicine. If symptoms are partially relieved, the headaches return, and in this case the next dose is taken 2 hours after the first dose. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. you should not continue taking the medicine. If the symptoms are partially relieved, the headaches return and, in this case, the next dose is taken 2 hours after the first dose. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. headaches come back and in this case the next dose is taken 2 hours after the first dose. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. headaches come back and in this case the next dose is taken 2 hours after the first dose. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan is given as a single dose to children or given as 5 mg over a 24-hour period. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness. Rizatriptan should be administered with caution to patients allergic to rizatriptan. Rizatriptan may cause drowsiness or dizziness.

What is sumatriptan?

Sumatriptan is a 5-HT receptor agonist and inhibits calcitonin gene-related peptide. Sumatriptan decreases the activity of the trigeminal nerve. Sumatriptan, which is a member of the triptans, treats migraines and is overused in the treatment of acute migraines. Sumatriptan is taken orally, topically through the nose, and parenterally as injections under the skin. When sumatriptan is administered subcutaneously, the maximum plasma concentration is reached after 12 minutes of dosing and sumatriptan has a bioavailability of 97% after subcutaneous dosing. The bioavailability after oral administration of sumatriptan nasal spray is 14% to 17%. Sumatriptan has an elimination half-life of 1-2 hours. Sumatriptan is primarily metabolized by MAO-A and its metabolites are excreted in the urine. The subcutaneous dose of 6 mg of sumatriptan relieves headache in 70% of patients. Oral and nasal doses of sumatriptan are also effective; the onset of action after nasal doses is approximately 15 minutes. The oral dose of sumatriptan is 25 mg to 100 mg, and after the first dose, the next oral dose can be taken after 2 hours, and in the period of 24 hours, the total oral dose of 200 mg can be taken . For the nasal spray, 5 mg to 20 mg of sumatriptan are administered and the nasal dose can be repeated after 2 hours and in 24 hours a total nasal dose of 40 mg can be administered to patients. Sumatriptan causes rare but serious cardiac events, such as coronary artery vasospasm, atrial and ventricular arrhythmias, myocardial infarction, and transient myocardial ischemia. 80% of patients experience at least one side effect after a subcutaneous dose of sumatriptan. Subcutaneous injections of sumatriptan also cause mild pain and a stinging sensation at the injection site. Bitter taste is the most common adverse effect after a nasal dose of sumatriptan. Sumatriptan is contraindicated in patients with ischemic and vasospastic coronary artery disease. Subcutaneous injections of sumatriptan also cause mild pain and a stinging sensation at the injection site. Bitter taste is the most common adverse effect after a nasal dose of sumatriptan. Sumatriptan is contraindicated in patients with ischemic and vasospastic coronary artery disease. Subcutaneous injections of sumatriptan also cause mild pain and a stinging sensation at the injection site. Bitter taste is the most common adverse effect after a nasal dose of sumatriptan. Sumatriptan is contraindicated in patients with ischemic and vasospastic coronary artery disease.

Key differences

  1. Rizatriptan is available as Rizatriptan Benzoate, on the other hand Sumatriptan
  2. Rizatriptan finds its use in acute migraines and for tension-type headaches, while sumatriptan is preferably treated for acute migraines only.
  3. Rizatriptan tablets are available, on the other hand, sumatriptan is available as tablets, nasal sprays, and subcutaneous injections.
  4. Rizatriptan reaches peak plasma concentration within 1-1.5 hours after oral dosing, while sumatriptan reaches peak plasma concentration within 1-2 hours after oral dosing.
  5. Rizatriptan reaches an oral bioavailability of 45%, on the other hand, sumatriptan reaches an oral bioavailability of 14%-17%.

Final Thought

The main conclusion from the above discussion is that Rizatriptan and Sumatriptan belong to the triptans and are used for the treatment of acute migraines.

Leave a Reply

Your email address will not be published.

CAPTCHA


Back to top button