Medicine

Difference Between Losartan and Lisinopril

Main difference

The main difference between losartan and lisinopril is that losartan is an angiotensin II receptor antagonist and lisinopril is an angiotensin converting enzyme (ACE) inhibitor.

Losartan versus lisinopril

Losartan is the angiotensin II receptor blocker; on the other hand, lisinopril is the angiotensin converting enzyme (ACE) inhibitor. The starting dose of losartan is 50 to 100 mg daily, while the starting dose of lisinopril is 2.5 to 5 mg daily. Losartan prevents stroke in patients with left ventricular failure and patients with hypertension, on the other hand, lisinopril does not prevent stroke in such patients. The bioavailability of losartan is 32%, while the bioavailability of lisinopril is 25%. Losartan is used in diabetic nephropathy, on the other hand, Lisinopril does not find its use in diabetic nephropathy. Losartan is not used in heart failure and after an acute attack of heart attack,

Comparison chart

losartan Lisinopril
Losartan is an angiotensin II receptor antagonist, used for hypertension and some other cardiovascular problems. Lisinopril is an angiotensin converting enzyme (ACE) inhibitor used to treat high blood pressure and heart failure.
drug category
Angiotensin II receptor blocker Angiotensin converting enzyme inhibitor
Bioavailability
The bioavailability of losartan is 32%. The bioavailability of lisinopril is 25%.
Initial dose
The starting dose is 50 mg per day and can be increased to 100 mg per day which can be taken all at once or in divided doses. The starting dose is 2.5 mg to 5 mg daily.
therapeutic uses
Hypertension, Prevents stroke in patients with hypertension, Prevents stroke in patients with left ventricular hypertrophy, Diabetic nephropathy Hypertension, After an acute heart attack, Heart failure
What is Losartan?

Losartan is the angiotensin II receptor antagonist and is used to treat hypertension. Losartan finds its use in the treatment of heart failure, left ventricular enlargement, and diabetic kidney disease. Losartan is taken by mouth and can be taken alone or in combination with other blood pressure lowering medications. Losartan shows its full therapeutic actions in six weeks. Losartan administration leads to a decrease in total peripheral resistance and cardiovenous return. Losartan antagonizes all physiological effects of angiotensin II. As a consequence of the pharmacological effects of Losartan, plasma renin activity increases. The reason for this is the elimination of angiotensin II feedback. The uricosuric effect of Losartan makes it significant among all members of this group. Losartan inhibits the uptake of uric acid in cells. As a result, more uric acid is available in the bloodstream that can be filtered and excreted by the kidneys. Losartan should not be taken with a potassium supplement or with potassium-containing salts as it causes hyperkalaemia. Losartan is well absorbed when taken orally and undergoes first-pass metabolism. 5-carboxylic acid metabolite and this metabolite is a long-acting antagonist at the AT receptor and contributes to the therapeutic effects of losartan. The bioavailability of losartan is approximately 32%. The cytochrome P450 isoenzyme plays an active role in the metabolism of Losartan. The maximum plasma concentration of losartan is reached within 1 hour after an oral dose. Losartan is excreted in urine, feces, bile as unchanged drug and metabolite. Following oral dosing, losartan is excreted 4% unchanged in the urine. and 6% is excreted as the active metabolite in the urine. Losartan is toxic to the fetus and should not be used during pregnancy, especially after the first trimester. One should not use Losartan if they are allergic to Losartan.

Example

Losartan containing major brand name is Cozaar

What is Lisinopril?

Lisinopril is an angiotensin converting enzyme (ACE) inhibitor. Lisinopril is used to treat heart failure, blood pressure, and heart attack. Lisinopril is the first-line treatment for hypertension. Lisinopril in diabetic patients prevents kidney disease. Lisinopril is taken orally and shows its full pharmacological effects within four weeks. Lisinopril is an analog of enalapril. Lisinopril exhibits its pharmacological actions by blocking the angiotensin converting enzyme in the renin-angiotensin-aldosterone system. This leads to the excretion of sodium along with the water in the urine and retention of potassium ions. The absorption of Lisinopril is not affected by any type of food. The bioavailability of lisinopril is poor and the maximum plasma concentration of lisinopril is reached within 7 hours. The duration of therapeutic action is 24-30 hours. Plasma protein binding of lisinopril is not found. Lisinopril is soluble in water and is not metabolized in the liver. Lisinopril is excreted unchanged in the urine. The half-life of lisinopril is 12 hours and the half-life is increased in patients suffering from kidney disease. Headache, tiredness, dizziness, cough, nausea, and rash are side effects of lisinopril. Lisinopril can cause some serious side effects, including liver problems, low blood pressure, angioedema, and high blood potassium levels. Lisinopril is not recommended for use during pregnancy as it may harm the baby and is classified as a pregnancy category D drug. Patients with a history of angioedema or who are allergic to any member of the Ace inhibitors should not take this drug. If the patient is taking sacubitril,

Example

Lisinopril that contains a major brand name is Zestril.

Key differences

  1. Losartan is the angiotensin II receptor inhibitor, on the other hand Lisinopril is an angiotensin converting enzyme (ACE) inhibitor
  2. Losartan is initially given at a dose of 50 to 100 mg daily, while lisinopril is initially given at a dose of 2.5 to 5 mg daily.
  3. Losartan shows its therapeutic action in the prevention of stroke in hypertensive and left ventricular failure patients, on the other hand, Lisinopril lacks this property.
  4. Losartan shows a bioavailability of 32% while Lisinopril shows a bioavailability of 25%.
  5. Losartan is not used in myocardial infarction and after an acute attack of heart attack, on the other hand, Lisinopril is used both in myocardial infarction and after an acute attack of heart attack.
  6. Available generic Losartan is Losartan Potassium while available generic Lisinopril is Lisinopril.

Final Thoughts

The conclusion from the above discussion is that losartan and lisinopril belong to two different groups of classes and are commonly used for the treatment of hypertension and some other cardiovascular problems.

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