Medicine

Difference Between Ibuprofen and Naproxen

Main difference

The main difference between ibuprofen and naproxen is that ibuprofen has a shorter half-life of 2 hours and naproxen has a longer half-life of 14-28 hours, depending on the age of the patient.

ibuprofen versus naproxen

Ibuprofen is a short-acting pain reliever, while naproxen is a long-acting pain reliever. Ibuprofen is slightly less effective for analgesia and relief of morning stiffness, while naproxen is slightly more effective for analgesia and relief of morning stiffness. Ibuprofen has the unchanged risk of myocardial infarction; on the other hand, naproxen has a 10% lower risk of myocardial infarction. Ibuprofen causes fewer gastrointestinal problems, while naproxen causes more gastrointestinal problems. Ibuprofen has available concentrations of 200 to 800 mg, while naproxen has available concentrations of 250 to 500 mg. Ibuprofen increases the negative effects of cyclosporins on kidney function;

Comparison chart

ibuprofen Naproxen
Ibuprofen is a short-acting nonsteroidal anti-inflammatory drug and is a derivative of propionic acid used to treat pain. Naproxen is a long-acting nonsteroidal anti-inflammatory drug and is a derivative of propionic acid used to treat pain.
drug category
Steroid-free anti-inflammatory drug Steroid-free anti-inflammatory drug
Mechanism of action
Non-selectively inhibits the enzyme cyclooxygenase. Non-selectively inhibits the enzyme cyclooxygenase.
Sales Available
ibuprofen sodium naproxen sodium
Interaction with aspirin
Ibuprofen interacts with the antiplatelet effects of aspirin. Naproxen interacts with the antiplatelet effects of aspirin.
Half life
2 hours 14-28 hours
Overdose
Treatment of overdose may include gastric lavage, use of laxatives, respiratory support, and intravenous fluids. Overdose can lead to stomach bleeding, so seek emergency help.

What is ibuprofen?

Ibuprofen is the most widely used non-steroidal anti-inflammatory drug and chemically belongs to propionic acid derivatives. Ibuprofen is approved as a symptomatic treatment in different medical situations such as rheumatoid arthritis, acute gouty arthritis, osteoarthritis, and ankylosing spondylitis. Ibuprofen is available in pharmacies and pharmacies without a prescription. Ibuprofen is available in the form of tablets where its concentration varies from 200 mg to 800 mg, but only 200 mg tablets can be taken in pharmacies without a prescription. Ibuprofen when taken orally is avidly bound to proteins, with 90% being metabolized by hepatic metabolism and its metabolites eliminated by renal excretion. Ibuprofen has a half-life of 2 hours and its antiarthritic effects persist even after plasma levels decline. Rheumatoid arthritis and osteoarthritis are treated with doses of 800 mg when given four times a day, but for mild rheumatoid arthritis and osteoarthritis pain, lower doses can also be used to relieve that pain. Ibuprofen at a dose of 400 mg is taken every 4-6 hours for the treatment of primary dysmenorrhea. Ibuprofen is the best option for those patients who cannot tolerate aspirin and indomethacin, but even some patients show gastrointestinal side effects after using ibuprofen. Ibuprofen has very few side effects, but the ones that are seen are headaches, dizziness, thrombocytopenia, blurred vision and in some cases amblyopia, edema due to fluid retention. Ibuprofen can cause eye disorders and, in this case, its use should be discontinued. The use of ibuprofen in pregnant women is occasional;

Example

Famous brands that contain ibuprofen are Advil, medipen, etc.

What is naproxen?

Naproxen is a nonsteroidal anti-inflammatory drug and is classified as propionic acid derivatives. Naproxen when taken orally is completely absorbed. The presence of food in the stomach affects the rate of absorption of naproxen, but does not affect the extent of absorption of naproxen. Naproxen reaches peak plasma concentration 2-4 hours after drug administration. Naproxen can be absorbed when administered rectally, but rectal administration of naproxen leads to less absorption compared to oral naproxen absorption. Naproxen has a variable plasma half-life, for example, in the young it is 14 hours and 28 hours in the elderly, and the reason for this delay is the decline in renal function due to increasing age. Approximately 30% of naproxen undergoes 6-demethylation. Naproxen and its metabolites are excreted as glucuronoid and other conjugates. Naproxen is 90% completely bound to plasma proteins when taken in therapeutic doses. Naproxen crosses the placental membranes and appears in the milk of nursing mothers. Naproxen shows gastrointestinal disturbances. Naproxen also shows some CNS side effects like drowsiness, headache, dizziness, sweating due to fatigue, and several other dermatological problems. Some patients are also allergic to naproxen and show symptoms of itching and different types of dermatological problems. Rare cases of jaundice, impaired kidney function, angioedema are also seen in patients taking naproxen. Naproxen crosses the placental membranes and appears in the milk of nursing mothers. Naproxen shows gastrointestinal disturbances. Naproxen also shows some CNS side effects like drowsiness, headache, dizziness, sweating due to fatigue, and several other dermatological problems. Some patients are also allergic to naproxen and show symptoms of itching and different types of dermatological problems. Rare cases of jaundice, impaired kidney function, angioedema are also seen in patients taking naproxen. Naproxen crosses the placental membranes and appears in the milk of nursing mothers. Naproxen shows gastrointestinal disturbances. Naproxen also shows some CNS side effects like drowsiness, headache, dizziness, sweating due to fatigue and various other dermatological problems. Some patients are also allergic to naproxen and show symptoms of itching and different types of dermatological problems. Rare cases of jaundice, impaired kidney function, angioedema are also seen in patients taking naproxen. Some patients are also allergic to naproxen and show symptoms of itching and different types of dermatological problems. Rare cases of jaundice, impaired kidney function, angioedema are also seen in patients taking naproxen. Some patients are also allergic to naproxen and show symptoms of itching and different types of dermatological problems. Rare cases of jaundice, impaired renal function,

Example

Naproxen brand names are Synflex, Aleve, etc.

Key differences

  1. Ibuprofen is a long-acting NSAID, while naproxen is a short-acting NSAID.
  2. Ibuprofen is less effective for analgesia, on the other hand naproxen is more effective for analgesia.
  3. Ibuprofen has a half-life of 2 hours, while naproxen has a half-life of 14 to 28 hours.
  4. Ibuprofen does not affect the risk of myocardial infarction while naproxen reduces the risk of myocardial infarction by 10%.
  5. Ibuprofen leads to fewer gastrointestinal disturbances due to its short duration of action; on the other hand, naproxen causes more gastrointestinal disturbances due to its long duration of action.

Final Thought

The conclusion from the above discussion is that ibuprofen and naproxen are propionic acid derivatives and are non-steroidal anti-inflammatory drugs that are widely used in the treatment of pain due to their pharmacological actions.

Leave a Reply

Your email address will not be published.

CAPTCHA


Back to top button