Difference between glycolysis and Krebs cycle

Main difference

Glycolysis and the Krebs cycle are the pathways of biochemistry. Both are of great importance. Glycolysis is the breakdown of glucose into pyruvic acid with the help of an enzyme. It comes in carbohydrate metabolism. In glycolysis, 2 NADH and 4 ATP are formed, and 2 ATP are used, so the energy of glycolysis is 8 ATP molecules. On the other hand, the Krebs cycle is the sequence of reactions in living organisms that use and produce water and CO2 as by-products and form ATP molecules. Furthermore, the Krebs cycle is the main oxidation cycle of carbohydrates, lipids and proteins. In the Krebs cycle, 3 NADH, 1 FADH and 1 GTP are produced and no ATP is used. Thus, the energy of the Krebs cycle is 12 ATP molecules.

Comparative chart

Glycolysis Krebs cycle
Principal function Glycolysis deals with carbohydrate metabolism. The Krebs cycle is the main oxidation cycle of carbohydrates, lipids, and proteins.
Training In glycolysis, 2 NADH and 4 ATP are formed, and 2 ATP are used, so the energy of glycolysis is 8 ATP molecules. In the Krebs cycle, 3 NADH, 1 FADH, and 1 GTP are produced, and ATP is not used. Thus, the energy of the Krebs cycle is 12 ATP molecules.
Reaction It is a linear chain reaction. It is a cyclical reaction.
Enzymes Glycolysis has different enzymes such as phosphohexo isomerase, hexokinase, aldolase, dehydrogenase, kinase, mutase, and enolase. The Krebs cycle has different enzymes such as pyruvate dehydrogenase, citrate synthase, Aconitase, Isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinyl synthase, succinyl dehydrogenase, fumarase, and malic dehydrogenase.
What is glycolysis?

It is one of the carbohydrate metabolisms. In this, the breakdown of glucose takes place resulting in the formation of pyruvic acid. Glycolysis is the series of reactions that includes different enzymes; These oxidize the six-carbon sugar (glucose) into a three-carbon compound, pyruvic acid is related to the production of ATP molecules. Glycolysis has a total of nine stages in which 1 st , 3 rd , and 9 th steps are irreversible.

These steps are as follows:

  • Glucose is converted into glucose six phosphates.
  • Glucose 6 phosphates in fructose 6
  • Fructose 6 Phosphate in fructose 1, six bisphosphates.
  • Fructose 1, six bisphosphates in glyceraldehyde three phosphate and dihydroxyacetone phosphate.
  • Glyceraldehyde three phosphate and dihydroxyacetone phosphate in 1, three bits of phosphoglyceric acids.
  • Three phosphoglyceric acids in three phosphoglyceric acids.
  • Three phosphoglyceric acids in two phosphoglyceric acids.
  • Two phosphoglyceric acids in phosphoenol pyruvic acid.
  • Pyruvic acid phosphoenol in pyruvic acid.

The enzymes involved in these steps are phosphohexo isomerase and aldolase that are used in the second and fourth steps of this process, respectively. Glycolysis is of two types; one is aerobic glycolysis and the other is anaerobic glycolysis. In aerobic glycolysis, 2 NADH and 4 ATP are formed, and 2 ATP are used, so the energy of glycolysis is 8 ATP molecules, while in anaerobic glycolysis, 2 NADH and 4 ATP are formed and 2 ATP are used 2 NADH, so the energy of anaerobic glycolysis is 2 molecules of ATP.

What is the Krebs cycle?

The Krebs cycle is also called the citric acid cycle. The Krebs cycle is the sequence of reactions in living organisms that use oxygen and produce water and CO2 as by-products and form ATP molecules. Furthermore, the Krebs cycle is the main oxidation cycle of carbohydrates, lipids and proteins. In the Kreb cycle, 3 NADH, 1 FADH, and 1 GTP are produced and ATP is not used. Thus, the energy of the Kreb cycle is 12 ATP molecules.

The Krebs cycle process has the following steps:
  • Pyruvic acid combines with Ach and oxaloacetic acid to form citric acid.
  • Citric acid in cis-aconitic acid.
  • Cis-Aconitic acid in isocitric
  • Iso-citric acid in alpha-ketoglutarate.
  • Alpha-ketoglutarate in succinyl-CoA.
  • succinyl-CoA in succinic acid.
  • Succinic acid in fumaric acid.
  • Fumaric acid in malic acid.
  • Malic acid in oxaloacetic acid.
  • Oxaloacetic acid combines again with pyruvic acid and Ach and the cycle goes

The enzymes involved in the above steps are pyruvate dehydrogenase, citrate synthase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinyl synthase, succinyl dehydrogenase, and malic dehydrogenase.

Glycolysis cycle vs.

  • Glycolysis deals with carbohydrate metabolism, while the Krebs cycle is the main oxidation cycle of carbohydrates, lipids, and proteins.
  • In glycolysis, 2 NADH and 4 ATP are formed, and 2 ATP are used, so the energy of glycolysis is 8 ATP molecules, while in the Krebs cycle 3 NADH, 1 FADH and 1 GTP are produced and not ATP is used. Thus, the energy of the Krebs cycle is 12 ATP molecules.
  • Glycolysis is a straight chain reaction, while the curb cycle is a cyclical response.
  • Glycolysis has different enzymes like phosphohexo isomerase, hexokinase, aldolase, dehydrogenase, kinase, mutase and enolase and on the contrary of this; The Krebs cycle has different enzymes such as pyruvate dehydrogenase, citrate synthase, Aconitase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinyl synthase, succinyl dehydrogenase, fumarase, and malic dehydrogenase.

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